Lipophilicity of lupeol semisynthetic derivates
نویسندگان
چکیده
منابع مشابه
Lipophilicity study of salicylamide.
Molecular lipophilicity was studied using salicylamide as a model drug. Log P value for the target compound was experimentally determined by the shake-flask method and calculated using nine different computer programs based on atom/fragment contributions, structural parameters, atom-type electrotopological-state indices and neural network modeling, or topological structure descriptors. Our anal...
متن کاملIsolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity
The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a–j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB231, IMR32and A549 cell lines. This all compound showed moderate activities.
متن کاملLupeol alkanoates in Brazilian propolis.
High temperature high resolution gas chromatography coupled to mass spectrometry (HT-HRGC-MS) isa powerful analytical tool. In this work we applied this technique to the study of crude extracts of propolis collected near the city of Uberlândia-Minas Gerais State. Eucalyptus trees and native plants from "cerrado" (savannah) were the material sources disposable for the Apis mellifera bees. A lot ...
متن کاملMonotonicity , Convexity and Symmetric Derivates
If the first lower symmetric derívate of a continuous function is nonnegative, then it is nondecreasing. If the second lower symmetric derívate of a continuous function is nonnegative, then it is convex. In this paper it is shown that if continuity is replaced by Baire one, Darboux in each of these, then the resulting statements are true.
متن کاملCrystalline semisynthetic ribonuclease-S'.
Crystals of solid phase-derived semisynthetic ribonuclease-S' were prepared and compared with those for native ribonuclease-S' and -S. The semisynthetic species used was the noncovalent complex of synthetic fragment-(1-20), corresponding to residues 1 through 20 of bovine pancreatic ribonuclease-A (ribonucleate 3'-pyrimidino-oligonucleotidohydrolase, EC 3.1.4.22), and native ribonuclease-S-(21-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu
سال: 2015
ISSN: 1899-3192,2392-0041
DOI: 10.15611/pn.2015.411.08